Featured publications
Single-Cell Analysis in Cerebrovascular Research:Primed for Breakthroughs and Clinical Impact
December 30, 2024
Data generated using single-cell RNA-sequencing has the potential to transform understanding of the cerebral circulation and advance clinical care. However, the high volume of data, sometimes generated and presented without proper pathophysiological context, can be difficult to interpret and integrate into current understanding of the cerebral circulation and its disorders. Furthermore, heterogeneity in the representation of brain regions and vascular segments makes it difficult to compare results across studies. There are currently no standards for tissue collection and processing that allow easy comparisons across studies and analytical platforms. There are no standards either for single-cell data analysis and presentation. This topical review introduces single-cell RNA-sequencing to physicians and scientists in the cerebrovascular field, with the goals of highlighting opportunities and challenges of applying this technology in the cerebrovascular field and discussing key concepts and knowledge gaps that can be addressed by single-cell RNA-sequencing.
Asher J. Albertson, Ethan A. Winkler, MD, PhD, Andrew C. Yang, PhD, Marion S. Buckwalter, MD, PhD, Andra L. Dingman, MD, Huihui Fan, MD, PhD, Paco S. Herson, PhD, Louise D. McCullough, MD, PhD, Miguel A. Perez-Pinzon, PhD, Lauren H. Sansing, MD, MS, Dandan Sun, MD, PhD, and Nabil J. Alkayed, MD, PhD. Single-Cell Analysis in Cerebrovascular Research:Primed for Breakthroughs and Clinical Impact. Preprint ahead of publication. 2024 Dec 30.; doi: https://doi.org/10.1161/STROKEAHA.124.049001.
Stroke and Motor Recovery are Associated with Regional and Age-Specific Changes in Periodic and Aperiodic Cortical Activity
November 7, 2024
Utilizing EEGs from healthy individuals and individuals with stroke, we found unique age and location dependent associations between aperiodic cortical activity and stroke. Interestingly, we also noted a unique relationship to long term motor performance. We believe this work offers insight into the unique ways the aged brain responds to injury.
Asher J. Albertson, Eric. C. Landsness, Margaret Eisfelder, Brittany M Young, Bradley Judge, Matthew R. Brier, Matthew J. Euler, Steven C. Cramer, Jin-Moo Lee, Keith R Lohse. Stroke and Motor Recovery are Associated with Regional and Age-Specific Changes in Periodic and Aperiodic Cortical Activity. Preprint ahead of publication. 2024 Nov 7. bioRxiv 2024.11.07.622359; doi: https://doi.org/10.1101/2024.11.07.622359.
Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivity
August 15, 2022
Albertson AJ, Landsness EC, Tang MJ, Yan P, Miao H, Rosenthal ZP, Kim B, Culver JC, Bauer AQ, Lee JM. Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivity. Neuroimage. 2022 Aug 15;257:119287. doi: 10.1016/j.neuroimage.2022.119287. Epub 2022 May 17. PMID: 35594811; PMCID: PMC9627742.
Recent publications
- Caring for Coma after Severe Brain Injury: Clinical Practices and Challenges to Improve Outcomes: An Initiative by the Curing Coma CampaignCuring Coma Collaborators, Apr 2025, In: Neurocritical Care. 42, 2, p. 325-333 9 p., 101432.Research output: Contribution to journal › Article › peer-review
- Single-Cell Analysis in Cerebrovascular Research: Primed for Breakthroughs and Clinical ImpactAlbertson, A. J., Winkler, E. A., Yang, A. C., Buckwalter, M. S., Dingman, A. L., Fan, H., Herson, P. S., McCullough, L. D., Perez-Pinzon, M. A., Sansing, L. H., Sun, D. & Alkayed, N. J., Apr 1 2025, In: Stroke. 56, 4, p. 1082-1091 10 p.Research output: Contribution to journal › Review article › peer-review
- Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivityAlbertson, A. J., Landsness, E. C., Tang, M. J., Yan, P., Miao, H., Rosenthal, Z. P., Kim, B., Culver, J. C., Bauer, A. Q. & Lee, J. M., Aug 15 2022, In: NeuroImage. 257, 119287.Research output: Contribution to journal › Article › peer-review
- Clinical problem-solving: Fever and rapidly progressive weakness in an immunocompromised patientAlbertson, A. J., Dietz, A. R., Younce, J. R. & Varadhachary, A. S., Oct 2018, In: Neurohospitalist. 8, 4, p. 194-198 5 p.Research output: Contribution to journal › Article › peer-review
- Bilateral Bow Hunter’s Syndrome Mimicking a Classic Seizure SemiologyAlbertson, A. J. & Kummer, T. T., Aug 1 2018, In: Neurocritical Care. 29, 1, p. 105-109 5 p.Research output: Contribution to journal › Article › peer-review
- HCN channel modulation of synaptic integration in GABAergic interneurons in malformed rat NeocortexAlbertson, A. J., Bohannon, A. S. & Hablitz, J. J., Apr 19 2017, In: Frontiers in Cellular Neuroscience. 11, 109.Research output: Contribution to journal › Article › peer-review
- Regulation of epileptiform discharges in rat neocortex by HCN channelsAlbertson, A. J., Williams, S. B. & Hablitz, J. J., Oct 2013, In: Journal of neurophysiology. 110, 8, p. 1733-1743 11 p.Research output: Contribution to journal › Article › peer-review
- Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampusRyley Parrish, R., Albertson, A. J., Buckingham, S. C., Hablitz, J. J., Mascia, K. L., Davis Haselden, W. & Lubin, F. D., Sep 17 2013, In: Neuroscience. 248, p. 602-619 18 p.Research output: Contribution to journal › Article › peer-review
- Decreased hyperpolarization-activated currents in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasiaAlbertson, A. J., Yang, J. & Hablitz, J. J., Nov 2011, In: Journal of neurophysiology. 106, 5, p. 2189-2200 12 p.Research output: Contribution to journal › Article › peer-review
- A novel animal model to study hot flashes: No effect of gonadotropin-releasing hormoneAlbertson, A. J. & Skinner, D. C., Sep 2009, In: Menopause. 16, 5, p. 1030-1036 7 p.Research output: Contribution to journal › Article › peer-review